Claudia Crestini is author of 14 patents, 2 books and in excess of 148 publications on international refereed journals, and over 180 scientific oral & poster contributions at international conferences, meetings and focused thematic schools.
Director of a Research Group consisting of 1 Associate professor, 1 assistant professor, 1 Post-doctoral Fellow, 3 Ph D Student, 3 Graduate Students.
Her papers have been cited over 5000 times and her h-index is 42 (Google scholar).
The scientific activity of Prof. Claudia Crestini is focused on different aspects of lignin and tannins Chemistry.
Director of a Research Group consisting of 1 Associate professor, 1 assistant professor, 1 Post-doctoral Fellow, 3 Ph D Student, 3 Graduate Students.
Her papers have been cited over 5000 times and her h-index is 42 (Google scholar).
The scientific activity of Prof. Claudia Crestini is focused on different aspects of lignin and tannins Chemistry.
highlights
The paper: Synthesis of Nano- and Microstructures from Proanthocyanidins, Tannic Acid and Epigallocatechin-3-O-Gallate for Active Delivery. Green Chem. 2017 19 (21), 5074–5091 was selected among HOT manuscripts in Green Chemistry in 2017.
The paper: Milled Wood Lignin: A Linear Oligomer. by C Crestini, F Melone, M Sette and R Saladino. Biomacromolecules 2011 12 11 PMID: 21928799 DOI: 10.1021/bm200948r has been selected for evaluation by Faculty of 1000 (F1000)
Faculty of 1000 (F1000) identifies and evaluates the most important articles in biology and medical research publications. Articles are selected by a peer-nominated global 'Faculty' of the world's leading scientists and clinicians who then rate them and explain their importance.
On average, 1500 new evaluations are published each month; this corresponds to approximately 2% of all published articles in the biological and medical sciences.
Evaluation details:
Must Read [8]
Controversial, Technical Advance, New Finding
Evaluation comments:
This article presents evidence that the lignin molecule is startlingly smaller than commonly depicted. The usual textbook portrayal of lignin is as a complex, heterogeneous aromatic polymer, built up of many phenylpropanoid units that form an extensive cross-linked network – often described as macromolecular. Size estimates often are quoted as 20-100 kilodalton (kDa) or more, implying several hundred phenylpropanoid residues in a polymer chain, but these estimates are notoriously 'iffy' because of artifacts in extracting the lignin and in the techniques for measuring this hydrophobic polymer, which aggregates in aqueous solutions. This article reports on the results of a nuclear magnetic resonance (NMR)-based method of end-group titration to conclude that milled softwood lignin has a degree of polymerization of 11 or less, and hardwood lignin is only slightly larger (18 or less). Thus, oligomer would be a better description of lignin. A similar conclusion is mentioned for poplar lignin by Stewart et al. {1}, although the detail is so obscure that most readers would likely miss it.
Lignin is important because it strengthens woody materials and protects cellulose from enzymatic attack – effects that are easy to imagine for a macromolecular, cross-linked, hydrophobic network, but less obvious for a small linear oligomer. If the conclusions of this article are correct, it should change our view of cell wall construction and possibly lead to new approaches for wall deconstruction in the cellulosic biofuel field.
References:
{1} The effects on lignin structure of overexpression of ferulate 5-hydroxylase in hybrid poplar.
Stewart JJ, Akiyama T, Chapple C, Ralph J, Mansfield SD
Plant Physiol. 2009 Jun; 150(2): 621-35PMID: 19386808 DOI: 10.1104/pp.109.137059
The paper: Milled Wood Lignin: A Linear Oligomer. by C Crestini, F Melone, M Sette and R Saladino. Biomacromolecules 2011 12 11 PMID: 21928799 DOI: 10.1021/bm200948r has been selected for evaluation by Faculty of 1000 (F1000)
Faculty of 1000 (F1000) identifies and evaluates the most important articles in biology and medical research publications. Articles are selected by a peer-nominated global 'Faculty' of the world's leading scientists and clinicians who then rate them and explain their importance.
On average, 1500 new evaluations are published each month; this corresponds to approximately 2% of all published articles in the biological and medical sciences.
Evaluation details:
Must Read [8]
Controversial, Technical Advance, New Finding
Evaluation comments:
This article presents evidence that the lignin molecule is startlingly smaller than commonly depicted. The usual textbook portrayal of lignin is as a complex, heterogeneous aromatic polymer, built up of many phenylpropanoid units that form an extensive cross-linked network – often described as macromolecular. Size estimates often are quoted as 20-100 kilodalton (kDa) or more, implying several hundred phenylpropanoid residues in a polymer chain, but these estimates are notoriously 'iffy' because of artifacts in extracting the lignin and in the techniques for measuring this hydrophobic polymer, which aggregates in aqueous solutions. This article reports on the results of a nuclear magnetic resonance (NMR)-based method of end-group titration to conclude that milled softwood lignin has a degree of polymerization of 11 or less, and hardwood lignin is only slightly larger (18 or less). Thus, oligomer would be a better description of lignin. A similar conclusion is mentioned for poplar lignin by Stewart et al. {1}, although the detail is so obscure that most readers would likely miss it.
Lignin is important because it strengthens woody materials and protects cellulose from enzymatic attack – effects that are easy to imagine for a macromolecular, cross-linked, hydrophobic network, but less obvious for a small linear oligomer. If the conclusions of this article are correct, it should change our view of cell wall construction and possibly lead to new approaches for wall deconstruction in the cellulosic biofuel field.
References:
{1} The effects on lignin structure of overexpression of ferulate 5-hydroxylase in hybrid poplar.
Stewart JJ, Akiyama T, Chapple C, Ralph J, Mansfield SD
Plant Physiol. 2009 Jun; 150(2): 621-35PMID: 19386808 DOI: 10.1104/pp.109.137059